Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention

Abstract

Objective: Obesity is considered as a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNPs) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce.

Methods: We analyzed the effect of two different SNPs (INSIG2:rs7566605, FTO:rs9939609) on the change of weight status in a one-year lifestyle intervention among 280 overweight children (mean age 10.8years, mean BMI 28.1kg/m²).

Results: The children reduced their mean SDS-BMI by -0.28 (95%CI -0.32 to -0.23). Modeling the impact of different genotypes and their statistical interactions on SDS-BMI change adjusting for age, gender and baseline BMI or SDS-BMI, respectively, revealed that the combination of CC-genotype in INSIG2 and AA-genotype in FTO was significantly associated with the lowest degree of overweight reduction, but even with increase in overweight (SDS-BMI change +0.51 (95%CI 0.22 to 0.79).

Conclusions: These findings provide some evidence that effects of different genotypes aggravate each other concerning weight change.

Results: The children reduced their mean SDS-BMI by 0.28±0.02. The frequencies were 7% CC-genotype for INSIG2 and 26% AA-genotype for FTO. Modeling the impact of different genotypes and their statistical interactions on SDS-BMI change adjusting for age, gender and baseline SDS-BMI revealed that the combination of CC-genotype in INSIG2 and AA-genotype in FTO was significantly associated with the lowest degree of overweight reduction (SDS-BMI +0.60±0.18; p=0.001; BMI +3.24±1.26/m²; p=0.011).

Conclusions: These findings provide some evidence that effects of different genotypes aggravate each other concerning weight change.